American Airlines was a major operator of the Boeing 757-200. It operated the type from July 1989, with up to 177 757-200s in the fleet (based on data from ch-aviation). In 2004, they operated 175,000 flights (over 10% of the network), but this declined soon after. By 2014, the type had just 6.1%, and it fell to 1.1% in 2019.