Which Airlines Fly From Chicago To South America?

Chicago O’Hare International Airport (ORD) is one of America’s largest and most important international travel gateways, with nonstop flights to nearly 250 different destinations as of September 2024. From intercontinental connections to Europe, Asia, the Middle East, and beyond to regional feeder routes operated by both United Airlines and American Airlines, it is fairly easy to get from Chicago-O’Hare to almost anywhere on the planet.