Risks of Decompression Sickness and Venous Thromboembolism during Spaceflight and Patent Foramen Ovale Implications

NASA’s Office of the Chief Health and Medical Officer formed a working group in August 2026 to review the most recent data related to extravehicular activity (EVA) prebreathe testing and decompression sickness (DCS) events, venous thromboembolism (VTE) in-flight occurrences, and patent foramen ovale (PFO) implication as they relate to NASA’s Artemis (lunar and beyond) missions. The recommendations from this working group are built upon and integrate the outcomes of previous working groups hosted by OCHMO.

NASA’s Integrated Medical Model (IMM)

Planning crewed missions to the Moon and Mars involves preparing for the medical realities of long-duration space travel. Factors like cosmic radiation, microgravity, and distance from Earth create unique health considerations for astronauts. To anticipate these needs ahead of time, NASA developed the Integrated Medical Model (IMM). The IMM is a decision-support tool that uses […]

Establishing Crew Exposure Limits of Martian Dust

Background Human exploration of Mars will expose crews to a persistent, fine particulate environment whose physicochemical properties and health implications remain only partly understood. Because no samples of authentic Martian airborne dust have been returned to Earth, NASA must rely on lunar dust toxicology, Martian regolith simulants, and extensive rover/lander geochemical and mineralogical datasets to […]

Establishing a VTE Risk Score for Astronauts Algorithm

In April 2026, NASA’s Office of the Chief Health and Medical Officer (OCHMO) initiated a working group to review updated VTE case information, additional data gathered revealing altered blood flow status within a cohort of astronauts, and discuss progress of research and clinical activities intended to mitigate the risk of VTE during spaceflight with new […]

Human Rating and NASA-STD-3001

Human-rating is a critical certification process that validates the safety, reliability, and suitability of space systems—including orbiters, launch vehicles, rovers, spacesuits, habitats, and other crewed elements—for human use and interaction. This process ensures that systems are designed not only to protect human life but also to accommodate human needs and effectively integrate human capabilities. Human-rating requires […]

Risk of Venous Thromboembolism During Spaceflight

In October 2024, NASA’s Office of the Chief Health and Medical Officer (OCHMO) initiated a working group to review the status and progress of research and clinical activities intended to mitigate the risk of venous thromboembolism (VTE) during spaceflight. The working group took place over two days at NASA’s Johnson Space Center; a second meeting […]